I am mostly a P365 carrier/shooter now, but for a couple years a P320 Compact was my primary handgun (with an X5 P226 SAO for competition); I put probably 15-20k rounds through the P320 (1k round classes, etc, back when ammo was $150-180/case) (and never got the drop-safe mod done), and no problems. So it's some combination of QC, specific units, and bad luck -- but even a 0.001% risk of something happening is a big deal.

The quick P250 -> P320 without really designing it properly does seem to have been a mistake, though.