Most newer handguns don't have manual safeties. The ones that do should be carried with it on. If you carry with it off, you won't have the muscle memory to switch it off in the event it is accidentally engaged. Basically, if it has the safety, you should be doing the motion for disengaging it regardless of it's starting position. Some people still choose to carry with it off. You get into all sorts of odd stuff the more you look into it, such as MARSOC rubber-banding their 1911 grip safeties.

Some additional context here https://news.ycombinator.com/item?id=44675889

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sgjohnson 2 days ago | parent [-]

FWIW I love the 1911-style grip safety. It’s a shame that more guns don’t have that.

	▲	topspin 12 hours ago \| parent [-]
		The Springfield XD line has this. At least one S&W Shield model as well. Both are excellent pistols. Not that you're wrong: grip safeties aren't common. It's amazing to me this P320 problem exists. Making semi-autos safe, even without a grip safety, has been a solved problem for over 40 years. How anyone thought a fully cocked striker is a reasonable design, or that the US military would adopt such a thing, is a disturbing mystery. After Sig gets financially destroyed, and the US military has to correct this monumental mistake, we can at least look forward to no further designs like this. Who knows, maybe the US will do something intelligent and just issue Glock 17's, like they should have done at least 20 years ago.