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elcritch 9 hours ago

Anyone know if there’s lab tests for ImP already? Is it a common or well known enough target?

drjasonharrison 6 hours ago | parent | next [-]

Another paper describes how imidazole propionate serum levels were measured: https://www.nature.com/articles/s41467-020-19589-w

"""Imidazole propionate serum measurements

ImP was quantified using ultra-performance liquid chromatography coupled to tandem mass spectrometry according to previous work. Briefly, serum samples were extracted with 3 volumes of ice-cold acetonitrile containing internal standards (13C3-labeled ImP and urocanate). After derivatization to butyl esters using 5% hydrochloric acid in butanol, the samples were separated on a C18 column using a gradient consisting of water and acetonitrile. Quantification was made using an external calibration curve16."""

So yes, but no.

nextos 8 hours ago | parent | prev [-]

These are typically measured using liquid chromatography coupled to tandem mass spectrometry. That also gives the opportunity to measure thousands of other metabolites, and thus get a broader picture of health. Unfortunately, commercial B2C metabolomics is not there yet. It's mostly used in population genomics research.