Indeed, I, Robot is made up entirely of stories in which the Laws of Robotics break down. Starting from a mindless mechanical loop of oscillating between one law's priority and another, to a future where they paternalistically enslave all humanity in order to not allow them to come to harm (sorry for the spoilers).

As for what Asimov thought of the wisdom of the laws, he replied that they were just hooks for telling "shaggy dog stories" as he put it.