There was an episode of House that took a deep dive down this rabbit hole, "Ignorance is Bliss":

https://house.fandom.com/wiki/Ignorance_is_Bliss

> But at the top of the episode is the relationship between Sidas and his wife Dara. Years before, Sidas realizes that he derives only anxiety from his work as the pressure on him to come up with even more brilliant ideas becomes unbearable. This parallels House's recent breakdown when House realizes the satisfaction he derives from his work is at risk, and then finds that it's the only thing that makes his life bearable. Both Sidas and House try to find solace in relationships, but they both have severe deficits when trying to bond with people – their intellect gets in the way. Sidas seems to have found the answer – a way to turn his intellect down to normal without damaging it permanently. He does it because he truly cares for Dara and realizes that in his "clear" state, he will punish her for her limited intellect.

lack of knowledge allows one to avoid what produces the suffering or depression for others to acquire such knowledge or relaizations

by virtue of being dumb one protects itself from much of the fuck ups of the world by staying oblivious to their existance in the first place

knowledge is both the cure and the curse, venom is in the dosage and every patient has different tresholds