Assuming someone else fixes the issues that might come up.

One of the pain points from Python is exactly native libraries and getting them compiled.

Sure, but that’s the general maintenance risk. I don’t think native code changes that dynamic, particularly in ecosystems where it’s the norm. And doubly so for cryptographic code, where native is the norm for performance and certification reasons.

It’s my impression as a maintainer of many projects that native compilation hasn’t been a driving issue in Python packaging for a while now. Most users download wheels and sidestep the entire problem. Whether or not they should trust random binaries from the internet is of course a bigger question.