One difference is that Python's type system is unsound. You can write code that passes `mypy --strict` but still contains functions that, for example, claim to return an `int` but actually return a `list` [0]. AFAIK it's not possible to circumvent Go's type system in such a way.

[0] https://news.ycombinator.com/item?id=43508152

The biggest limitation of Go's static type system vs. Python's type hints system that I can think of would be the lack of union types, with nullability a close second (and it's just a specialized application of union types in Python). An interface in Go can be anything under the hood, though you at least know that, whatever its concrete type, it does implement the methods exactly as defined.

You can definitely circumvent Go's type system with unsafe operations (with FFI also recognized as inherently unsafe) but that's a clear boundary that you know you're crossing (albeit not quite as clear as e.g. in Rust).