In zero tolerance Sweden, nitrous is oddly perfectly legal. In fact, I recently got a cheerful flyer from our municipal waste disposal company announcing that empty 1L nitrous bottles can now be left with common household hazardous waste.

This is easily falsified by a cursory internet search about the physiological mechanism behind nitrous oxide's effects. It is appalling that a medical professional would so confidently give you an uneducated, crackpot answer. The exact same mechanism which knocks you out gives you euphoria at lower doses.

If someone holds their breath long enough to cause hypoxia when inhaling nitrous oxide, they have other problems. You can easily hold your breath 1-2 minutes while sitting on a couch without experiencing hypoxia. If you're experiencing euphoria as strong as what nitrous oxide causes from hypoxia, you're basically about to die.

This is why you shouldn't trust experts on stuff outside their speciality, this answer is just wrong.

You don't even need to research it, the lived experience of being in a dentist office with mixed oxygen and nitrous produces the recreational effects - if it was mostly hypoxia, having oxygen mixed in would have a greatly diminished "recreational" effect.

I mean, it is true most people doing it recreationally are giving themselves mild to severe hypoxia, but that doesn't mean the effect is caused by hypoxia

Bullshit. You aren't supposed to be hypoxic when using nitrous. You take a half-breath of air, and then breathe in the n2o.

So the tetany in breathwork is generally caused by the decreased CO2 concentration causing respiratory alkalosis (ie blood gets more alkaline and has a ph balance of > 7.5), which in turn causes the protein albumin to bind more strongly to calcium and not release it as it's supposed to, and calcium is an important regulator in voltage gated ion channels in neurons.

Long story short, your neurons get just a tad bit more excitable because calcium that usually acts like the bouncer to the hot club is busy snogging albumin. That has very little effect in places in the body, but in motor neurons that control your smallest muscles (face and hand), and in sensory neurons under your skin it does move the needle — that causes the muscles to contract and your skin to feel tingly, both exactly the same cause.

This is the reason people with epilepsy should _NOT_ do breathwork, but for otherwise healthy adults there are no negative long term effects of respiratory alkalosis — a few normal breaths to balance out your co2 and the symptoms will go away.

Could you please explain more about the Ref[2], what does it mean beyond what is in article and how serious is it? "These findings suggest that breath-hold diving training over several years may cause mild, but persistent, short-term memory impairments"

Can you tell more about recreational nitrous oxide and when does the "damage occur"? Is there the same thing with wim hof? (like for example with oximeter 80 Sp02 or below?) I got in wimhof/oxide around 80 Sp02 the interesting thing is I got this feeling with fighting to hold my breath but below 90 I kinda needed to convince myself that I should breath in both cases,

Thank you, this is terrific! Why should tetany be worrisome?

Edited to add: the second article seems to be about decompression injuries, rather than apnea-induced brain damage?