I love that in Guix, Guile is used as the configuration language all the way "from the metal" (the bootloader) to the declarative environment config in userspace.

I'm one of those folks that still can't do LISPs though. If there was a way to replace some or all of the parens with significant indentation instead (which I believe Racket makes possible... but that only works in Racket), I might reconsider it.

You probably heard this one before. After a while the parens do disappear. When conventionally indented, lisp users see only the indentation and not the parens.

With structural editing, no one ever have to match parens or count parens at the end...

YMMV ofcourse.