F5 sells expensive boxes intended for larger installations where you can afford not to do ACME in the external facing systems.

Giving the TLS endpoint itself the authority to manage certificates kind of weakens the usefulness of rotating certificates in the first place. You probably don't let your external facing authoritative DNS servers near zone key material, so there's no reason to let the external load balancers rotate certificates.

Where I have used F5 there was never any problem letting the backend configuration system do the rotation and upload of certificates together with every other piece of configuration that is needed for day to day operations.