In lieu of an e-ink monitor, I use a hotkey to toggle "Grayscale" filtering on my Mac.

It's taking some of the addictiveness out of my screen viewing.

On the trip to my local recycling center I immediately did a double take when I saw a pair of Eizo GX540 monochrome medical diagnostic displays sitting there. I've got these babies hooked up and I can see myself using this e-ink mode and the grayscale nature of these monitors. Although these monitors weren't intended for productivity they are very good at editing B&W photography, terminal work, and even old films.

I use this setting often, together with Increase Contrast, through the Accessibility Shortcuts menu. For whatever reason, my computer feels more peaceful and calm with those on, even if it's worse and uglier too.

How did you assign it to a hotkey? I'm sure there's at least a dozen ways to do it, but I couldn't find a simple one without installing additional software.

I have this setting on my Android phone at night to make it awful to use.