No its literally just a statistics issue. Say you screen someone for a 1 in a million disease with a 0.001% false positive rate. If you find something and have to do a biopsy to figure out if its a real issue or not, you will have 99.9% of them be for nothing. Biopsies are actually risky procedures that can have dangerous complications that can and do harm people. Say your biopsy has a 99% accuracy. This means even after all that someone with a confirmed biopsy only has a 10% chance of having the disease, and may get dangerous and life changing treatment for nothing.