Seeing something like this or Akira on the big screen there is an analogue patina to meticulous hand drawn motion and some of the effects like the physically process glow effects of the neon lights in Akira that do give a very different feeling than a CG shot.

Although only a few will really appreciate why it's different I definitely think the difference has a heavy effect on the vibe of a movie.

Same with shooting on film vs digital, not that digital is worse it has it's own feeling which can be used with intent.