Yes mixing is just like with VB.NET.

When mixing, you often write business logic as self-contained F# libraries with a C#-friendly API; and use C# to integrate them with whatever imperative, reflection-heavy and DI-heavy frameworks .NET is promoting the current year, since those are filled with interop edge cases for F# anyway.

You really want to avoid a language sandwich though (e.g. C#/F#/C#), because you'll keep wishing to remove the middle layer. Sadly, the addition of source generators make this mistake even more appealing.