> is pretty straightforward to accept without fear of charge-backs or fraud

Well yeah, it's a great option for the seller. You get non-recourse cash before shipping the item. The real question is why people are willing to send it to you. From the other side, it's basically asking to be defrauded.

You can have escrow or something using a 2-of-3 multisignature if you are worried, but you can also just have trust mechanisms outside of the payment network.