> That's interesting. I was just reading about how high dose IV vitamin c can induce cell death in a wide variety of cancers, but somehow, despite this being known for decades, nobody has done rigorous research on it.

Sigh. Vitamin C quackery again.

Vitamin C at high doses is cytotoxic, so it works against rapidly dividing cells. Cancer cells also preferentially concentrate vitamin C because they are under oxidative stress.

However, just like with most of other generally cytotoxic treatments, cancer cells quickly evolve resistance to it. And the overall toxicity of vitamin C makes it uninteresting as a treatment.

This was just published by UI showing a potent effect of high dose vitamin C + chemotherapy: https://medicine.uiowa.edu/content/high-dose-iv-vitamin-c-pl... and https://www.sciencedirect.com/science/article/pii/S221323172...

There is evidence that high doses of antioxidants can make cancer worse, probably because cancer cells are under oxidative stress.

https://www.cancer.gov/news-events/cancer-currents-blog/2015...

https://pubmed.ncbi.nlm.nih.gov/8127329/

Thanks for providing a plausible explanation. Do you know of any links (ideally peer- reviewed research) supporting the quick evolution of resistance to vitamin C? If not I'll google around.