I think it might have more to do with the specific implementation than the tool.

Most incarnations of C# offer a GC.Collect method and an ability to configure the threading model around collections. Used properly, you can keep maximum delays well-bounded. You still have to work your ass off to minimize allocations, but when some do inevitably occur due to framework internals, etc., you don't want to have to clean up 3 hours worth of it at once. Do it every frame or scene change.