The Slime Mold Time Mold article is maybe an interesting starting point, but really not great analysis... see this thorough rebuttal around the Lithium stuff that has not been responded to: https://www.lesswrong.com/posts/7iAABhWpcGeP5e6SB/it-s-proba...

TBH a lot of the discourse around this annoys me because it ignores sort of fundamental obvious stuff like food/snacks got way tastier, access to unhealthier food is higher, we live a way more sedentary lifestyle, takeout got more affordable, studies show that people overall consume more calories from unhealthier sources, you can go to the grocery store and see you should basically avoid much of the food there, food spikes your glucose higher, more artificial ingredients, switch from fat to sugar, more processed ingredients, etc. and yet everyone says "well it can't just be that" because XYZ specific study of some quality and timeframe took one of those axis in some degree of isolation and showed that _maybe_ it's not that specific thing only. Kind of a missing the forest for the common sense trees aspect. Obviously we don't understand the whole picture of obesity, but there's a degree of denial around common sense health stuff that's really weird in the kind of "rationalists try to figure out obesity" writing. I really think we should work more from a place of "you don't see people who do moderately intense exercise regularly and eat healthily being overweight/obese" as a baseline...