Yeah, desk against the wall is a common setup (except in open-plan offices, where it's desk against a desk). However, when setting up my current home office, I opted for a different layout. It's similar to this:

https://www.ex-astris-scientia.org/gallery/other/defiant-rea...

but with an L-shaped standing desk from IKEA, with windows on the right side (behind the auxiliary desk), doors on the left, and remaining wall surface filled with random assortment of cabinets and wardrobes.

Having the desk in the middle doubled the usable wall surface area I could put closets and cabinets against. Also, I have something behind the screen for eyes to refocus on, reducing the strain.

(Also, I was totally going for the "Starfleet ready room" style; that's as close as I got. It's really hard to capture the feel without a proper carpet; unfortunately, I have dust mite allergy, so that's off the table.)