Proper thread placement and numa handling does have a massive impact on modern amd cpus - significantly more so than on Xeon systems. This might be anecdotal, but I’ve seen performance improve by 50% on some real world workloads.

When I was caring more about hardware configuration on databases in big virtual machine hosts not configuring NUMA was an absolute performance killer, more than 50% performance on almost any hardware because as soon as you left the socket the interconnect suuuuucked.