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Mistletoe 3 days ago

I’m ignorant about cloning progress made since Dolly. Have they made advances on the problem where the clones have accelerated aging because they are made from cells that are aged?

>On 14 February 2003, Dolly was euthanised because she had a progressive lung disease and severe arthritis.[6] A Finn Dorset such as Dolly has a life expectancy of around 11 to 12 years, but Dolly lived 6.5 years.

https://en.wikipedia.org/wiki/Dolly_(sheep)

Or was it even a problem at all? It seems clones made later haven’t had that issue? It shows the power of a meme in installing that idea in the consciousness of society.

Google is telling me this in its AI answer.

>Research suggests that telomeres are rejuvenated during nuclear reprogramming by somatic cell nuclear transfer (SCNT).

inciampati 3 days ago | parent [-]

Telomere length is dynamically regulated. It sounds like SCNT does well at triggering the correct reprogramming to reset epigenetic features that might have led to Dolly's troubles (although it seems these were greatly overstated: https://blog.cirm.ca.gov/2016/07/27/cloning-breakthrough-dol...)