Remix clone Hacker News

Again, food addiction and satiety is a different question than if CICO works. If you can't stop eating and cram too many calories because you eat too many... burgers and potato chips or whatever, that has nothing to do with if CICO works. I have yet to see evidence that shows that caloric restriction if properly, truly controlled, does not result in weight loss for the vast, vast majority of obese individuals. People are notoriously bad at estimating calories and knowing how much they eat, so any study that is self-reported is inherently going to be problematic.

Should we do more research to find if anything anything specific that may be causing overeating or food non-satiety? Sure. Is the answer likely to be something that is essentially 'tastier food is easier to overeat, and tastier food is much more available than it used to be'? I suspect that is the likely conclusion.

I think GLP1 agonists are a great tool to be used to create that so-called 'willpower' to stop overeating (or, an easy way to reduce food noise, whatever you want to call it). The next step is figuring out how, as a society, we make it easier for folks to make that lifestyle change without a constant stream of 'willpower drugs' for the rest of their life.

▲

unshavedyak 3 days ago | parent [-]

> Again, food addiction and satiety is a different question than if CICO works.

Yes, and again - as i said previously. No one is questioning if CICO works. That's like if questioning if physics works. No one is doing that. The laws of the universe are still intact. Talking about humans is the constructive conversion most people are having.

▲

Kirby64 3 days ago | parent [-]

> No one is questioning if CICO works. That's like if questioning if physics works. No one is doing that. The laws of the universe are still intact.

Other people are, in fact, questioning CICO. Look at the other commenter talking about base metabolism changes.

To put an analogy to this: Gambling addicts often lose lots of money at casinos. The behaviors that lead to them being addicted to gambling are in many ways likely equivalent to overeating problems. Nobody asks 'why are gambling addicts losing money?' because we know the reason (casinos have the house edge... you always lose on aggregate). And yet, with food, people consistently ask the question 'why are people so obese?' as if the answer isn't very obvious: they're eating too much food. It's purely as simple as that. The behaviors that lead to eating too much aren't nearly as focused on, in my opinion. Much time is spent on 'the kinds of foods eaten' and how specific things are bad for you, which is essentially like arguing that people should play more blackjack and less roulette or something.

▲

unshavedyak 2 days ago | parent [-]

> Other people are, in fact, questioning CICO. Look at the other commenter talking about base metabolism changes.

I disagree. CICO is fundamental physics. Just because metabolism changes does not mean you can produce more energy than you take in. CICO always applies, and it's so 'duh' that it's nearly pointless to discuss in my mind.

Their points about metabolism changes is that the details matter. Finding a way to break the cycle will yield more gains with the population than telling people to starve in a desert.

	▲	Kirby64 2 days ago \| parent [-]
		Metabolism changes are metabolism changes. What does the food you eat have anything to do with that, in practice? As far as I can tell, the mix of carbs/fat/protein has little to do with how much your body “compensates” from a surplus/deficit. If you don’t meaningfully have control over that, the only other real lever is how many calories you eat. Finding a way to lower calories without satiety problems or food noise issues ultimately is the solution. Some people do it via lots of low caloric foods (veg, mainly) that still have high satiety. Some people do it with Ozempic. Some people just aren’t bothered nearly as much by a caloric deficit no matter what they eat.