Yeah, I think caution is needed with a single study, especially with mice, when drawing conclusions about people.

However, this study is suggesting that semaglutide causes more muscle loss than would be expected based on calorie change alone, not just that weight loss is accompanied by muscle loss.

A lot of comments seem to be missing this critical part of the study.

I wouldn't be surprised if this doesn't replicate, but what they describe isn't quite what you might assume based on some of the comments in this thread.