Can you provide a single high quality (randomized) study demonstrating GLP1 therapeutics are 'incredibly detrimental to [your] longevity and quality of life'?

Consider the type of confounding that occurs in studies of people losing a lot of lean mass: cachexia, restriction to bed, famine.

Traditional weight loss methods have not shown the magnitude of survival benefits wrt cardiovascular disease, joint pain, diabetic complications. Exercise is wonderful, but as a public health intervention it is not sufficient.

If anyone looks at the totality of the high quality GLP1 clinical evidence and concludes these drugs are going to cause a net reduction in longevity and quality of life, then they should step back and assess their process for evaluating information.

Exercise is a public health intervention that actually works in improving health. It may not work to create actual weight loss, but it does improve things like blood pressure regardless.