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cyberax 7 months ago

> For the people who lift weights while on this/these drugs, how much lean muscle do they lose?

I was 92kg when I started on liraglutide (I was doing GLP-1 agonists before it was cool!) and 67% of muscle mass (61kg). I'm now at 69kg and 82% of muscle mass (56kg). I'm doing weight and resistance training twice a week, in addition to aerobic training.

One nice thing, while muscles don't become more massive, they for sure become more pronounced and visible with weight loss.

scotty79 7 months ago | parent | next [-]

I'd bet you are stronger now despite slightly lower muscle mass.

Probably the muscle tissue people lose first are crappy cells. Weak, nonfunctional, senescent or even maybe some muscle embedded fat.

cyberax 7 months ago | parent [-]

Muscle cells don't get replaced or cleaned. Like neurons, they basically stick around throughout the whole life.

Instead, it's the cells themselves that grow bigger or smaller.

metafunctor 7 months ago | parent | prev [-]

Those muscle mass percentages cannot be right. How were they measured?

NovemberWhiskey 7 months ago | parent | next [-]

I’m assuming that’s lean mass (100% - fat %) rather than muscle mass. Unless that person doesn’t have a skeleton.

cyberax 7 months ago | parent | prev [-]

Just the total mass minus the fat mass. Any further breakdown is not particularly useful.