> For the people who lift weights while on this/these drugs, how much lean muscle do they lose?

I was 92kg when I started on liraglutide (I was doing GLP-1 agonists before it was cool!) and 67% of muscle mass (61kg). I'm now at 69kg and 82% of muscle mass (56kg). I'm doing weight and resistance training twice a week, in addition to aerobic training.

One nice thing, while muscles don't become more massive, they for sure become more pronounced and visible with weight loss.

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scotty79 10 months ago | parent | next [-]

I'd bet you are stronger now despite slightly lower muscle mass.

Probably the muscle tissue people lose first are crappy cells. Weak, nonfunctional, senescent or even maybe some muscle embedded fat.

	▲	cyberax 10 months ago \| parent [-]
		Muscle cells don't get replaced or cleaned. Like neurons, they basically stick around throughout the whole life. Instead, it's the cells themselves that grow bigger or smaller.

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metafunctor 10 months ago | parent | prev [-]

Those muscle mass percentages cannot be right. How were they measured?

	▲	NovemberWhiskey 10 months ago \| parent \| next [-]
		I’m assuming that’s lean mass (100% - fat %) rather than muscle mass. Unless that person doesn’t have a skeleton.
	▲	cyberax 10 months ago \| parent \| prev [-]
		Just the total mass minus the fat mass. Any further breakdown is not particularly useful.