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From the abstract:

"Studies suggest muscle loss with these medications (as indicated by decreases in fat-free mass [FFM]) ranges from 25% to 39% of the total weight lost over 36–72 weeks. This substantial muscle loss can be largely attributed to the magnitude of weight loss, rather than by an independent effect of GLP-1 receptor agonists, although this hypothesis must be tested. By comparison, non-pharmacological caloric restriction studies with smaller magnitudes of weight loss result in 10–30% FFM losses."

The "surprising" part is kinda bullshit, and implies there's something special about glp-1s. It is the opposite of surprising that weight loss includes a lean mass loss.

That said, being skinnyfat is probably bad for you and the idea that you should work to preserve/build muscle and not only lose weight is a good one.

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mr_toad 5 days ago | parent [-]

FFM isn’t entirely muscle, but what other weight would be shed when losing FFM other than muscle?

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nordsieck 5 days ago | parent | next [-]

> FFM isn’t entirely muscle, but what other weight would be shed when losing FFM other than muscle?

I'm not an expert, but I have to imagine that most of it is muscle.

After dramatic weight loss, a person will probably lose some bone - particularly in the lower body - due to decreased loading.

I know body builders sometimes eat extremely high protein diets (more than 1 g/lbs of body weight) and lift quite hard to try to hang on to as much muscle mass as possible. And they still lose some when cutting.

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cthalupa 5 days ago | parent | prev | next [-]

Water weight is a big one, and is part of your FFM. I lost 10lb of water weight in my first 24 hours on tirzepatide.

Some of it is likely bone density as well. You can prevent the bone density and muscle loss with proper diet and exercise, though.

	▲	hombre_fatal 5 days ago \| parent [-]
		Googling it, 70% of FFM is water. Yeah, I've swung 10lbs in 24 hours just going from well fed to fasted without water. And it certainly wasn't fat I lost, just water and I'm surely any mass in my... various tracts.

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5 days ago | parent | prev [-]

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