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The lab wasn’t just studying coronaviruses. The director had intimate knowledge of gain-of-function techniques, with publications and grant proposals to document this. Some of the research was published during her tenure at the lab, so it can be assumed that the research was performed there.

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jounker 6 days ago | parent | next [-]

From what I know you’re mischaracterizing the research.

To the extent that they were looking at gain of function, they were also looking at loss of function. My understanding is that the research was looking at how random point mutation affect infectivity, both positively and negatively.

They were using also using virus evolutionary pretty distant from covid 19.

There are corona viruses present in species in the wet market that were much closer to covid 19. (eg pangolin caron’s viruses)

Blaming the wuhan lab is like finding that your child has been eaten by a tiger and the blaming a house cat breeder on the other side of town.

	▲	tripletao 6 days ago \| parent [-]
		The WIV had the largest program in the world to sample novel sarbecoviruses from nature. At the beginning of the pandemic, the published virus closest to SARS-CoV-2 (RaTG13) was from the WIV. Closer viruses (BANAL) have since been published, by a different group but from areas where the WIV was also recently sampling. There's no serious question that the WIV has unpublished viruses--even with no attempt at secrecy, every active research group has unpublished work. Researchers found an unpublished merbecovirus in contamination from shared equipment. This isn't related to SARS-CoV-2, but shows the claim that the WIV had zero unpublished viruses to be specifically false. Public access to the WIV's database of viral genomes was removed early in the pandemic, and never restored. https://www.biorxiv.org/content/10.1101/2023.02.12.528210v2 Pangolins were initially proposed as the proximal host, but that's been abandoned for years. After a long delay, the paper in Nature was extensively corrected, following Alina Chan's discovery that the alleged multiple samples were all from a single batch of smuggled pangolins. These were probably infected during trafficking, in the same way that housecats are sometimes infected by SARS-CoV-2 but aren't the source. https://www.nature.com/articles/s41586-020-2313-x https://www.biorxiv.org/content/10.1101/2020.07.07.184374v2 The goal of research like DEFUSE was gain of function, a deadlier or faster-spreading virus. That goal wasn't always successfully achieved, but that's true for all goals. The point is that skilled researchers specifically trying to achieve a goal (like by directed evolution during serial passage, or by genetic engineering) are much more likely to do so than would random point mutations alone. None of this means it's certain that SARS-CoV-2 arose from an accident at the WIV. The picture that you've received isn't accurate, though.

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WillPostForFood 6 days ago | parent | prev [-]

I agree, just not sure when the gain-of-function information really came out. It was being denied in congressional hearing pretty late in the process. The early speculation about the lab may not have been based on that knowledge.