It's lonely being an outlier, especially in a trait that's so fundamental to how you see the world. Despite best effort, it's hard to relate to most people, and they especially find it hard to relate to you. The delta of lived experience is quite wide, often insurmountable.

My smart friend said it's like everyone around you is slightly drunk.

I feel like this could be said about most human traits, on both ends of those traits’ axis. I’m not sure if that makes it insightful or obvious :).