I did some Qt programming in Python (PySide6), but ran into segfaults, which should of course not happen no matter what you do in a scripting language (except when using modules like ctypes). Many of these cases were related to object lifetime handling which is difficult to do correctly in Qt, and many people have written about it. In Python (a garbage-collected language) one should not have to worry about this.

I also use PySide. No segfaults, but I'm not doing anything complicated.