| 1. | ▲ | CRISPR tech selectively shreds cancer cells, including "undruggable" cancers (innovativegenomics.org) |
| 537 points by gmays 6 hours ago | 141 comments |
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| 2. | ▲ | I Am Not a Reverse Centaur (blog.miguelgrinberg.com) |
| 199 points by ibobev 4 hours ago | 135 comments |
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| 3. | ▲ | Swift at Apple: Migrating the TrueType Hinting Interpreter (swift.org) |
| 35 points by DASD 2 hours ago | 13 comments |
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| 4. | ▲ | How to setup a local coding agent on macOS (ikyle.me) |
| 150 points by kkm 4 hours ago | 52 comments |
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| 5. | ▲ | Malware developers added nuclear and biological weapons text to to their spyware (twitter.com) |
| 206 points by marc__1 a day ago | 142 comments |
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| 6. | ▲ | Pirates, a naval warfare game inspired by Sid Meier's Pirates (piwodlaiwo.github.io) |
| 129 points by iweczek 4 hours ago | 57 comments |
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| 7. | ▲ | Mmorpg World of ClaudeCraft, vibe coded with Fable 5 (worldofclaudecraft.com) |
| 14 points by beatthatflight an hour ago | 2 comments |
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| 8. | ▲ | Palantir loses legal challenge against Swiss investigative magazine (ft.com) |
| 36 points by sschueller an hour ago | 3 comments |
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| 9. | ▲ | Slightly reducing the sloppiness of AI generated front end (envs.net) |
| 143 points by FergusArgyll 7 hours ago | 97 comments |
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| 10. | ▲ | Launch HN: BitBoard (YC P25) – Analytics Workspace for Agents (bitboard.work) |
| 28 points by arcb 5 hours ago | 12 comments |
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| 11. | ▲ | "Don't You Just Upload It to ChatGPT?" (correresmidestino.com) |
| 190 points by speckx 4 hours ago | 170 comments |
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| 12. | ▲ | Where Did Earth Get Its Oceans? Maybe It Made Them Itself (quantamagazine.org) |
| 86 points by ibobev 6 hours ago | 50 comments |
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| 13. | ▲ | A PDF that changes based on how its read (sgaud.com) |
| 100 points by SarthakGaud 5 hours ago | 54 comments |
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| 14. | ▲ | Introduction to UEFI HTTP(s) Boot with QEMU/OVMF (blog.yadutaf.fr) |
| 59 points by jtlebigot 7 hours ago | 17 comments |
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| 15. | ▲ | Cosmodial Sky Atlas (killedbyapixel.github.io) |
| 22 points by memalign 3 hours ago | 1 comments |
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| 16. | ▲ | There Is Life Before Main in Rust (grack.com) |
| 55 points by mmastrac a day ago | 13 comments |
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| 17. | ▲ | Maxproof (arxiv.org) |
| 121 points by ilreb 10 hours ago | 10 comments |
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| 18. | ▲ | A dumpster arrived behind my university's library (yalereview.org) |
| 142 points by mooreds 7 hours ago | 121 comments |
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| 19. | ▲ | If you are asking for human attention, demonstrate human effort (tombedor.dev) |
| 1439 points by jjfoooo4 a day ago | 450 comments |
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| 20. | ▲ | Can I Buy Your KV Cache? (arxiv.org) |
| 5 points by MediaSquirrel an hour ago | 4 comments |
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| 21. | ▲ | A Call to Action: Stop the FCC's KYC Regime (blog.lopp.net) |
| 295 points by FergusArgyll 7 hours ago | 192 comments |
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| 22. | | Hazel (YC W24) Is Hiring a Full Stack Engineer (ycombinator.com) |
| 8 hours ago |
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| 23. | ▲ | Show HN: StackScope – I crawled over 40k indie launches to see what they ship (stackscope.dev) |
| 35 points by datafreak_ 6 hours ago | 12 comments |
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| 24. | ▲ | WASI 0.3 (bytecodealliance.org) |
| 212 points by mavdol04 8 hours ago | 83 comments |
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| 25. | ▲ | You can power on a Mac remotely (jeffgeerling.com) |
| 28 points by speckx 6 hours ago | 18 comments |
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| 26. | ▲ | Law Enforcement's "Warrior" Problem (2015) (harvardlawreview.org) |
| 74 points by bookofjoe 4 hours ago | 59 comments |
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| 27. | ▲ | Looking Forward to Postgres 19: It's About Time (pgedge.com) |
| 113 points by xngbuilds 5 hours ago | 33 comments |
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| 28. | ▲ | Encrypted Spaces An architecture for collaborative applications (encryptedspaces.org) |
| 55 points by _____k 9 hours ago | 7 comments |
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| 29. | ▲ | Most Beautiful Will Ever Made (1936) (paperspast.natlib.govt.nz) |
| 9 points by cf100clunk 3 hours ago | 1 comments |
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| 30. | ▲ | A jacket that harvests drinking water from the air (news.utexas.edu) |
| 154 points by ilreb a day ago | 96 comments |
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